Proton Pump Inhibitors (PPIs)
oton pump inhibitors (PPIs) are a group of medications that decreases the amount
of acid in the stomach and intestines.
Doctors prescribe PPIs to treat people with GERD, ulcers in the stomach or intestine,
or other digestive disorders that may cause excess stomach acid.
How do proton pump inhibitors work?
Your stomach produces acid to help break down food so it is easier to digest.
In certain circumstances, this acid can irritate the lining of your stomach and
duodenum (the upper part of your small intestine), causing indigestion and even ulcers.
The proton pump inhibitors work by completely blocking the production of stomach acid.
They do this by inhibiting (shutting down) a system in the stomach known
as the proton pump.
What is a proton pump?
The proton pump is a molecule in certain cells of the stomach.
It "pumps" acid into the stomach. It takes a non-acidic potassium ion out of the stomach
and replaces it with an acidic hydrogen ion. This hydrogen ion is what makes things acidic.
By putting more hydrogen ions into your stomach, the pump makes the contents
of your stomach more acidic.
But by stopping the action of the pump, acid secretion into the stomach is stopped.
What are PPIs used for?
Proton pump inhibitors are used in the treatment of GERD, stomach and duodenal ulcers,
erosive esophagitis, and Zollinger-Ellison syndrome.
Doctors may prescribe using PPIs alone, or in combination with antacids.
PPIs may also be used in combination with certain antibiotics (e.g. amoxycillin
and clarithromycin) when treating Helicobacter pylori (H. pylori)
infection (a bacterial infection of the stomach), which is thought to be one of the main
causes of recurring stomach ulcers.
Are there differences among PPIs?
PPIs are similar in how they work, and there is no evidence that one is more
effective than another. However, they differ in how they are broken down
by the liver and how they interact with other medications.
Also, the effects of some PPIs may last longer than others, and may be taken less frequently.
What are the different types of PPIs?
PPIs include:
Aciphex (raberprazole)
Dexilant (dexlansoprazole)
Nexium (esomeprazole)
Prevacid (lansoprazole)
Prilosec (omeprazole)
Protonix (pantoprazole)
Prilosec is also available in over-the-counter form as Prilosec OTC.
How are PPIs different from H2 Blockers?
Both PPIs and H2 Blockers suppress gastric acid secretion.
They are different, however, in how they do this.
While PPIs shut down the proton pumps in the stomach, H2 Blockers work by blocking
the histamine receptors in acid producing cells in the stomach.
PPIs have a delayed onset of action, while H2 blockers begin working
within an hour.
PPIs work for a longer period of time; most up to 24 hours
and the effects may last up to three days. H2 Blockers, however,
usually only work up to 12 hours.
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For more information about the individual Proton Pump Inhibitor
medications, please check
الرابط
دكتور كمال سيد الدراوىاو
https://www.google.com/#hl=en&output=search&sclient=psy-ab&q=proton+pump+inhibitors&oq=PROTON&gs_ 
موضوع: DRUGS IN COMMON USE 
الجمعة سبتمبر 28, 2012 9:57 am
